The latest medical imaging technology can help understand brain running

January 01, 2020

Brain Rainbow is a new brain imaging technology that helps scientists understand the brain's function by using fluorescent proteins to illuminate neurons inside the brain. Although these colorful pictures are like beautiful pictures hanging in modern art galleries, they are not works of art. In fact, they are just some of the latest technological achievements in the field of neurology.

Brain Rainbow is a new brain imaging technology

Free form: This brain rainbow map is taken from the brain of the experimental mouse and shows that the axons that regulate certain muscle contractions are scattered.

Free form: This brain rainbow map is taken from the brain of the experimental mouse and shows that the axons that regulate certain muscle contractions are scattered.

Neuronal subunits found in the retina of experimental mice: New imaging techniques help neuroscientists understand more about the principles of brain processing information.

Neuronal subunits found in the retina of experimental mice: New imaging techniques help neuroscientists understand more about the principles of brain processing information.

Neuronal scaffold. An image of a protein in axons. These axons form a fine molecular scaffold that makes the neurons thin and long and scattered throughout the brain. These samples were prepared by staining the antibodies with the extraordinary recognition of specific molecules for natural antibodies.

The researchers reportedly implanted mouse brain cells with specially treated fluorescent proteins that "light up" neurons, allowing researchers to study how the brain processes information. The technology is named Brain Rainbow, and its production gives neuroscientists the opportunity to study the living brain from within. When outside information flows into the brain, brain rainbows allow neuroscientists to better understand how neural circuits process information.

It is reported that this technology is derived from the utilization of fluorescent proteins of jellyfish. Scientists have discovered that injecting fluorescent proteins into the biological brain can illuminate cells inside the brain. Neuroscientist Carl Schonavier said in an interview with Human Invention: "Green fluorescent protein is found in a green jellyfish. People have been wondering why it is green. After years of research, people have calculated this green. The genetic coding of fluorescent proteins." By using very common genetic engineering techniques, you can implant this gene into any cell of the research object, making the cells appear green. The most prominent role of green fluorescent protein is in the living brain of experimental mice, so that you can study their brains as they grow.

Since the first use of green fluorescent protein, scientists have continued to develop fluorescent proteins of various colors. After these fluorescent proteins are embedded in neurons, individual cells are more prominent in the "jungle".

Schonavi is a doctoral student in neuroscience at Columbia University and a well-known science communicator. He explained: "If I want to study X neurons in the Y region of the animal brain, and I want to know the condition of these neurons when the animals grow, I only need to embed the fluorescent proteins activated by these genes into the brain cells of the animals. I only need to observe when the animals grow up. In the samples I studied, the brain cells embedded in the fluorescent protein were lit because they represent the role of a certain gene."

Schonnawi applied this technique to the brains of experimental mice, trying to study how information goes through the brain and as his doctoral subject. He said: "Information is transmitted to the brain through our eyes, limbs, nose, and from outside. This information is very primitive and unstructured noise, but our brains automatically and quickly organize this information with little effort. Get up and running. The question is, how does the brain work?"

The application of brain rainbow technology has enabled neuroscientists to gradually understand how neural circuits work together to process external information.

However, the development of the brain rainbow is still in its infancy, just as the telescope was invented, we can only look at the stars with our eyes. Schonnawi believes: "We are currently only touching the tip of the iceberg. Our brains have many interesting and great tools that run in their own powerful and powerful way, but we can't explain the truth of how these tools work. So we have to do tireless research."

Brain rainbow is only the germination stage of human research brain, but scientists like Schonnawi have gradually begun to understand the mechanism of complex neuron work.

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